Repair Damaged DNA + Combat the Effects of Photoaging

Anti-ageing methods have historically sought to replicate our skin’s natural defenses. But the latest products that promise to rejuvenate skin for a younger looking complexion have been born out of Nobel Prize-winning research. Based on an even deeper understanding of the skin’s natural healing process, DNA repair enzymes are the most ground-breaking skincare ingredient to date.

With warmer weather and sunnier days quickly approaching, it’s time to not only revamp your skincare regimen (repeat after us, “I will use sunscreen!”) but also start to address the damage your skin has already encountered over the years.

Hot Pursuit

In short, skin damage (and the subsequent signs of visible ageing) is caused by DNA damage, which occurs naturally as we age as well as when we are exposed to UV light and pollution.

Most of us have been relying on SPF for protection, along with anti-ageing powerhouses such as antioxidants to reduce the effects of age and environmental aggressors.


But these methods have limitations – as research shows sun damage continues up to three hours after exposure, making the use of a good sunscreen only half the battle.

And when speaking of past damage, experts claim that even if you slathered yourself in SPF50 every day for the rest of your life, you could not undo previous years of sun exposure.

So although protection and prevention remain the key for both younger-looking and healthier skin, it is how we repair the damage, past and present, which has caught the interest of the world’s leading skincare specialists.

Repair + Protect

Our skin naturally contains its own toolbox of enzymes to fix damaged DNA. But as we age, the levels of these enzymes drop — the repairs become less effective, and the wear and tear begins to show.

If DNA becomes damaged, and is not repaired properly, then the cell division can cause replication errors resulting in mutation or cell death. This can lead to various disorders such as prematurely aging skin.

And while antioxidants can absorb oxidants floating inside the cells that damage DNA, they cannot repair the damage.


So how can you repair the damage and achieve healthier, younger-looking skin? The answer lies in creams and serums that contain DNA repair enzymes.

DNA skin repair ingredients are typically based on enzymes derived from marine and botanical sources such as plankton. These enzymes work by restoring DNA that has been damaged by free radicals.

Encapsulated in Liposomes (tiny synthetic bubbles made of the same material as cell membranes) so they can be delivered deep into skin, DNA repair enzymes literally seek out damaged DNA in skin cells and then repair it. DNA repair enzymes work like a seamstress of sorts, cutting out the damage and then patching the holes with a piece of undamaged DNA, which is what makes them so revolutionary. Products that contain these enzymes have the potential to really make a difference in overall skin quality and health.

One of the greatest advantages of most DNA repair products is that unlike tretinoin and retinols (which should only be used at night), they do not interact with sunlight and can be used during the day.

One of the major skin care brands, Neova has been pioneering DNA repair products with successful results, and closely follows new research to continuously improve it’s formulations.

Neova’s DNA Total Repair serum uses a proprietary liposome delivery system, specifically engineered to transfer DNA repair enzymes deep into the cellular level of the epidermis, the site of DNA damage.

The DNA repair enzymes recognize DNA damage and excise the damage on each strand, speeding DNA recovery. DNA repair technology stimulates the body’s natural repair mechanisms to self-correct and reverse the visible signs of aging.


In clinical studies performed by Neova, skin was exposed to UVB radiation. After exposure, topical application of photolyase-containing liposomes was applied to UVB-irradiated skin for 60 minutes. Subsequent re-exposure to light decreased the number of UVB radiation-induced dimers by 45% and increased UV protection by 300%.

DNA repair enzymes have preventative qualities too, putting them at the forefront of research into skin cancer treatment.

Neova DNA Damage Control sunscreens feature two patented DNA repair enzymes  photolysomes and endosomes.  These liposome-encapsulated enzymes work with potent antioxidants to defend cells and accelerate the body’s ability to repair solar DNA damage.

Photolysomes are liposomes containing a plankton extract which use visible light to reverse the damage caused by UV, in a process called photoreactivation.

Endosomes contain an enzyme extract prepared from Micrococcus luteus, which was discovered after a complete search for an organism very resistant to UV radiation. The resistance of Micrococcus luteus is largely due to the presence of the enzyme UV endonuclease, which recognizes UV induced DNA damage and initiates its repair.
Delivery of these enzymes is well known to enhance removal of sun damage, increase cell survival and protect the immune system.5 In addition, it has shown to reduce the appearance of post-sunburn peeling.

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